Ho Hum, Cancer Is Still Stable

Stable but not ho-hum, actually. Thursday, April 29, was the end of Cycle 28 of my pomalidomide (CC-4047) trial at Mayo Clinic. M-spike is still 1.0 g/dL, IgG is actually down 5%, and light chains are normal. That's great! The fly in the ointment is the neutrophil count, which is down to 730 cells per uL, where the reference range is 1700 to 7000. In theory, at least, this leaves me a little too vulnerable to bacterial and fungal infections.


The trial protocol requires that the pomalidomide dosage be reduced if neutrophils fall below 1000. Last month, neutrophils were 940 per uL, but another CBC performed four days later at a local clinic showed a count of 1500. When that result was faxed to Mayo, the study was continued unchanged. This time the neutrophil count was even lower, but Dr L again suggested a re-test in four days, and by golly the count on Monday afternoon was 1700. Huh. No change in pomalidomide dosage for at least another month.

How can the neutrophil count change that much? More than double! I'm surprised that it can, actually, but: Hand Infection: Other Discussions with Dr L: Some current test results:

Test    Feb 04    Mar 04    Apr 01    Apr 29     Remarks
M-spike g/dL 1.0 1.0 1.0 1.0 Best tumor measure
IgG mg/dL 1180 1130 1070 1010 Variation is normal
L FLC mg/dL 2.78 2.10 1.82 2.41 L Free light chains
Calcium mg/dL 9.8 10.1 9.8 9.7 Below 10.2 is best
Creat mg/dL 1.1 1.0 1.2 1.3 Kidney, normal
HGB g/dL 14.2 14.7 14.6 14.1 Hemoglobin, normal
RBC M/uL 4.00 4.17 4.39 4.21 Red cells, normal
WBC K/uL 3.8 3.4 3.3 3.3 White cells, low
ANC K/uL 1.22 1.29 0.94 0.73 Neutrophils, LOW!

Related links:

My Myeloma     A discussion of my myeloma, not very technical.
My Treatment History Not technical.
My Test Charts Graphic displays of several key test results over time.
My Test Result Table Best with a wide browser window. Somewhat technical.
My Supplement Regimen With links to where I buy them.