December 11, 2008:

My myeloma is stable after Cycle 10 of the CC-4047/Dexamethasone trial. Cool. But watch out for elevated liver enzymes AST and ALT.

This particular 28-day cycle may have been affected by several unusual circumstances:

• First, I really did take the supplements almost every day;
• Three weeks ago I pulled a band-aid off the back of my hand and unknowingly lifted the skin right off with it, leaving a large open sore;
• That sore developed a large (ugly) scab;
• Which is healing, but only very slowly;
• I got a 24-hour flu or food poisoning nine days before the Mayo appointment, including stomach upset and a slight fever, with a complete recovery by the next morning; and
• Something, who knows what, has caused liver enzymes ALT and AST to be elevated. ALT was 87 U/L, with a reference range of 7-52, and AST was 69 U/L, with a reference range of 15-37.

The Mayo test results don't indicate much change in the cancer numbers. M-Spike, the most significant number, is 1.0 g/dL, same as last month. In fact it has not changed much since August, the first time it dropped as low as 1.0. IgG is up from 1170 mg/dL to 1260, but for good reason, see below. Free lambda light chains are up 24% to 4.03 mg/dL, but kappa chains are up even more and the ratio actually went up a bit, so free light chains are probably not really up. The only scowl in the group photo is the elevated liver enzymes. Other blood numbers like red cells, hemoglobin, and platelets are as expected, with white cells and neutrophils increased as one might hope in response to a flu threat.

I go to Mayo every 28 days. I meet with Dr L every other time, otherwise with nurse practitioner KDS. This time it was Dr L. Here are a few subjects that came up:

• The increase in IgG might easily be attributable to the flu episode, because the immunoglobulins produced to battle the flu could last weeks in the blood.
• Similarly, the increased free lambda light chains could be coming from those plasma cells that produced the extra IgG. I think that's what she said.
• Dr L did not suggest a possible reason for the elevated liver enzymes, except maybe the flu episode. Especially if that was actually food poisoning and not flu. There was a now-suspect cheese ball ...
• Happily, two other liver markers are NOT up. Bilirubin was one of those, and I don't remember the other. LDH can be a liver marker but she didn't do LDH this time.
• The only albumin measurement this time was the one that comes as a part of the electrophoresis tests (with M-spike), and she doesn't quite trust that albumin result.
• However, that albumin result was UP to 3.6 g/dL from 3.4 the month before. It's a liver marker too, and UP is the preferable direction for albumin, trustworthy or not.
• In any case I will have the liver enzymes checked again in two weeks, the day before Christmas. If they are still up, it will probably be a dry Christmas for me. No beer. Sigh.
• I asked Dr L if there is any therapy for skin - some way to toughen it. She didn't know of any.
• Perhaps this is more the domain of Dr HH, the naturopath. Time for another appointment with her?
• People (more than one) have actually suggested Mayo Clinic's "Vanicream" skin lotion to strengthen skin. So we bought a couple of jars of that before returning home. I'll try it, what the heck.
• For what it's worth, the first ingredient is purified water, the second is white petrolatum, and the third is cetearyl alcohol. That third item is described in Wikipedia as not an 'alcohol' like rubbing alcohol, but rather a moisturizer, emulsifier, and stabilizer.
• Dr L produced a chart on the computer that showed how CC-4047 (pomalidomide) stimulates the immune system in far more ways than thalidomide does.
• In contrast, dexamethasone suppresses the immune system.
• Yet the two together are more effective than either one alone. "Go figure," said Dr L. I guess there is more to be learned.
• Also, she believes that CC-4047 is strongly antiangiogenic, which means that it suppresses the creation of tiny new blood vessels. I got the impression that it exceeds thalidomide in this characteristic. Maybe Revlimid too. (CC-4047, Revlimid, and thalidomide are analogous immunomodulatory drugs.)
• We think that dexamethasone and other steroids are a cause of thinning skin.
• We also know that skin is constantly replenishing itself, wearing off from the outermost surface and rebuilding from below.
• I wondered if the rebuilding of skin might require the creation of tiny blood vessels, and if so, CC-4047 might interfere with the creation of new skin. She said that she always thought of the dex as the culprit in thin skin, but didn't discount this possibility either.
• Perhaps this could also account for the very slow rate of healing of injuries.
• Now I wonder if any other bodily organs might suffer from lack of an ability to rebuild. Does the heart rebuild itself? Lungs? Liver?
• I didn't discuss this with Dr L, but I notice that ALT and AST have been elevated before, in 2003 and 2004. Back then I believe that we attributed the temporary increase to running. I did a 5-mile run Wednesday night, less than 12 hours before this most-recent blood test. Could that be the cause? I'm thinking maybe so.
• The drive to Mayo is 90 minutes, and she gave me permission to drink black coffee on the way from now on, even though the first business on arrival is a blood draw. I will appreciate that.
• Of the 60 people in the CC-4047 trial, most are responding, including several for whom Revlimid has failed.
• One patient in particular was refractory to everything including Revlimid and Velcade, yet had an excellent response to CC-4047.
• Only two of the 60 patients are now progressing again.
• The generic name for CC-4047 will be pomalidomide, but the trade name will NOT be Actimid. Don't know what it will be.

Here are some related links:

	My Myeloma		A discussion of my myeloma, not very technical.
	My Treatment History		Not technical.
	My Test Charts		Graphic displays of several key test results over time.
	My Test Result Table		Best with a wide browser window. Very "technical."

Other side effects of the two key drugs, CC-4047 and dexamethasone, are discussed in a previous post.

Here are a few specific test results:

Test		Sep 16		Oct 16		Nov 13		Dec 11		Remarks
M-spike g/dL		1.0		0.9		1.0		1.0		Best tumor measure
IgG mg/dL		1180		1130		1170		1260		Variation is normal
L FLC mg/dL		2.64		3.14		3.25		4.03		Free light chains
Calcium mg/dL		9.7		9.6		9.8		1.1		Below 10.2 is best
Creat mg/dL		1.0		1.1		0.9		1.0		Kidney, lower is better
HGB g/dL		13.6		13.8		14.6		14.6		Hemoglobin, normal
RBC M/uL		3.90		3.97		4.19		4.20		Red cell count, low
WBC K/uL		5.3		4.4		4.3		5.3		White cells, normal

I'm still running 20 miles per week, getting set to increase that gradually back up to 40. Life is good.