November 13, 2008:

Perhaps the new CC-4047 drug has done the best it can. After nine four-week cycles in the phase-II trial, overall results are good but numbers are no longer improving. M-spike actually went up slightly this month for the first time, from 0.9 to 0.97, though still well down from the high of 2.7 at the start of the trial. This is also the first time that I have seen M-spike reported to the hundredths digit, though, so I wonder how significant that last digit really is, knowing that the electrophoresis test which measures M-spike isn't especially accurate anyway. In the final report it was rounded up to 1.0. IgG is virtually unchanged, and Lambda free-light chains (FLC) are up a little but so are Kappa light chains, and the ratio is unchanged.

White cell and red cell counts are mostly unchanged, also good. Hemoglobin is actually up a little. I bought a $25 blood pressure monitor and measured my blood pressure many times over the past few weeks, to get a better picture, and found that it is normal most of the time on the 12-mg dose of dexamethasone. Here is a chart of the blood pressure readings.

Because of muscle weakening, the doctor reduced my dex dosage from 12 mg per week to 8 mg per week for the upcoming 10th cycle. The entire protocol as prescribed by Dr. L is detailed in a previous post.

I skipped my supplements during this cycle, hence the "naughty Don" title. I didn't mean to at first, just forgot to take them, but when a week and a half had passed and I hadn't taken any yet, I decided to forget them for the rest of the cycle as an experiment. Result? This was the first cycle in which M-spike went up, if just a little. Maybe the supplements would have made a difference, maybe not, but I'm back on them now and we will see.

On this Mayo visit I met with Dr DS rather than Dr L, though Dr L did pop in for a moment. Dr DS is a certified nurse practitioner with special training in myeloma. She did a good job. I can't complain about my treatment at Mayo.

Here are some related links:

      My Myeloma     A discussion of my myeloma, not very technical.
My Treatment History Not technical.
My Test Charts Graphic displays of several key test results over time.
My Test Result Table Best with a wide browser window. Very "technical."

Side effects of the two key drugs, CC-4047 and dexamethasone, are discussed in a previous post.

Other subjects that came up: Here are a few specific test results:

Test Aug 22    Sep 16    Oct 13    Nov 11    Remarks
M-spike g/dL 1.0 1.0 0.9 1.0 Best tumor measure
IgG mg/dL 1040 1180 1130 1170 Variation is normal
L FLC mg/dL 3.57 2.64 3.14 3.25 Free light chains
Calcium mg/dL 9.3 9.7 9.6 9.8 Below 10.2 is best
Creat mg/dL 1.3 1.0 1.1 0.9 Kidney, lower is better
HGB g/dL 13.8 13.6 13.8 14.6 Hemoglobin, slightly low
RBC M/uL 3.99 3.90 3.97 4.19 Red cell count, low
WBC K/uL 4.4 5.3 4.4 4.3 White cells, normal

I'm still running - three marathons since September. Nineteen states now, only 33 to go :-) Life is good.

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