October 16, 2008:

Eight four-week cycles of the phase-II trial of the new Celgene drug CC-4047 are now complete, and overall results are great. M-spike dropped again this month from 1.0 to 0.9, down from a high of 2.7 at the start of the trial. YAY! IgG is virtually unchanged, and Lambda free-light chains (FLC) are up a little but so are Kappa chains, and the ratio is actually a bit higher (better).

White cell and red cell counts are mostly unchanged, also good. Blood pressure, which was about 150/80 two months ago, was down to about 122/58 this month, probably because Dr. L has reduced my dosage of dexamethasone (dex) from 20 mg once weekly to 12 mg. That 12-mg dosage continues for the ongoing ninth cycle. The entire protocol as prescribed by Dr. L is detailed in a previous post.

Here are some related links:

      My Myeloma     A discussion of my myeloma, not very technical.
My Treatment History Not technical.
My Test Charts Graphic displays of several key test results over time.
My Test Result Table Best with a wide browser window. Very "technical."

Side effects of the two key drugs, CC-4047 and dexamethasone, are discussed in a previous post.

Dexamethasone affects (increases) the level of glucose in blood, which is not good. Therefore, although I am not a diabetic, I occasionally use a blood glucose meter. I have previously measured blood glucose at roughly half-hour intervals on "dex day" when I was taking 40 mg of dex, and later 20 mg of dex, and also no dex (an ordinary day). Last Monday was dex day once again, like all Mondays, and I made those measurements after taking 12 mg of dex the night before. Here is a chart that shows the results for 40 mg, 20 mg, 12 mg, and no dex. Bottom line: 12 mg of dex last Monday resulted in blood glucose levels at least as high as they were on 20 mg of dex last May 19. That was a surprise to me, but not to Dr L, see below.

Other subjects that came up: Here are a few specific test results:

Test Jun 26    Jul 24    Aug 22    Sep 16    Remarks
M-spike g/dL 1.1 1.1 1.0 1.0Best tumor measure
IgG mg/dL 1450 1330 1040 1180Variation is normal
L FLC mg/dL 4.03 3.30 3.57 2.64Free light chains
Calcium mg/dL 10.1 9.7 9.3 9.7Below 10.2 is best
Creat mg/dL 1.0 1.0 1.3 1.0Kidney, lower is better
HGB g/dL 14.8 14.3 13.8 13.6Hemoglobin, a bit low
RBC M/uL 4.28 4.17 3.99 3.90Red cell count, low
WBC K/uL 5.5 4.7 4.4 5.3White cells, normal

Red cell count and hemoglobin are on the low edge. I will continue to try to treat those with sublingual B-12 for another month.

Meanwhile I'm still running and life is good.