September 16, 2008:

Seven four-week cycles of the phase-II trial of the new Celgene drug CC-4047 are now complete, and overall results are great. M-spike is unchanged this month at 1.0, but down from a high of 2.7 at the start of the trial. IgG is up a little but I have a cold which can make it go up, and Lambda free-light chains (FLC) are at the lowest level in five years of measuring them. Doctor L used the word "stable" to describe my myeloma. Stable is good.

White cell and red cell counts are mostly unchanged, also good. Blood pressure, which was about 150/80 last month, was down this month, probably because Dr. L reduced my dosage of dexamethasone (dex) from 20 mg once weekly to 12 mg. That 12-mg dosage continues for the ongoing eighth cycle. This is the entire protocol as prescribed by Dr. L:
Here are some related links:

      My Myeloma     A discussion of my myeloma, not very technical.
My Treatment History Not technical.
My Test Charts Graphic displays of several key test results over time.
My Test Result Table Best with a wide browser window. Very "technical."

Side effects of the two key drugs, CC-4047 and dexamethasone, are discussed in a previous post.

Other subjects that came up: Here are a few specific test results:

Test Jun 26    Jul 24    Aug 22    Sep 16    Remarks
M-spike g/dL 1.1 1.1 1.0 1.0Best tumor measure
IgG mg/dL 1450 1330 1040 1180Variation is normal
L FLC mg/dL 4.03 3.30 3.57 2.64Free light chains
Calcium mg/dL 10.1 9.7 9.3 9.7Below 10.2 is best
Creat mg/dL 1.0 1.0 1.3 1.0Kidney, lower is better
HGB g/dL 14.8 14.3 13.8 13.6Hemoglobin, a bit low
RBC M/uL 4.28 4.17 3.99 3.90Red cell count, low
WBC K/uL 5.5 4.7 4.4 5.3White cells, normal

Red cell count and hemoglobin are on the low edge. I will continue to try to treat those with sublingual B-12 for another month.

Meanwhile I'm still running and life is good.