We celebrate the end of cycle six of the phase-II trial of the new drug CC-4047. The first three monthly cycles brought very good results, then the fourth and fifth cycles not so much, but this sixth cycle seems to point to a continuing gradual decline in tumor burden. My two primary markers are IgG and M-spike. In this sixth cycle:

• IgG dropped 23%, from 1360 down to 1040 mg/dL. IgG does bounce around, though, as the immunoglobulins respond to internal bacterial and viral infections, so it could pop back up again in a month. Or not.
• M-spike went down 9%, from 1.1 to 1.0 g/dL. It is the best measure of monoclonal protein, which in turn is the best measure of total tumor burden other than a bone marrow biopsy. The ideal (and normal) value is zero.

The good news is:

1. The cancer does seem to be declining, if rather slowly, and
2. There really isn't any bad news.
3. Life is great!

Dr. L took my blood pressure two different ways and got numbers close to 150/80 each time, higher readings than I have ever had before. Ever. Maybe that's the bad news. I'm not too worried yet, though, because I have recently had very normal blood pressure readings too. Shouldn't my blood pressure be a bit high when visiting my oncologist? Yes, but maybe not in this case because she had already told me that the tumor burden seems to be going down.

Regardless, Dr. L knows that dexamethasone can cause high blood pressure, and is aware of the risks that it brings. She is concerned enough that she has reduced my weekly dose of dex from 20 mg to 12 mg. This does NOT displease me! I hate dex - I just ran a half marathon race ten minutes slower than one I ran in May, and I attribute most of the loss of speed to dex. I wonder what else it's doing to my body. Of course I hope that the reduction in dex will not significantly reduce the efficacy of the treatment.

We will continue with 2 mg of CC-4047 daily and 12 mg DEX once weekly for the seventh cycle. Here are some related links:

	My Myeloma		A discussion of my myeloma, not very technical.
	My Treatment History		Not technical.
	My Test Charts		Graphic displays of several key test results over time.
	My Test Result Table		Best with a wide browser window. Very "technical."

Side effects of the two drugs, CC-4047 and dexamethasone (DEX), are discussed in a previous post.

Other subjects that came up:

• Some people take their dexamethasone in the morning and some take it in the evening, so I asked if there is any difference in efficacy. Dr L said not, but there may be a difference in side effects, especially regarding sleep. Since I am not having much problem sleeping, I will continue to take it with dinner.
• I asked if normal plasma cells can replicate themselves. Dr L said that they do not replicate directly, but through progenitors called "memory B cells." These are the same cells that some researchers suspect of going wacko (technical term) and creating defective plasma (myeloma) cells in great quantity. These memory B cells are also resistant to the usual treatments, like CC-4047 and dex, which may be why myeloma always comes back.
• The treatment is reducing my markers rather slowly, so I asked if that predicted a poor outcome. She said that it may be just the opposite - that a fast treatment response can be followed by a fast return of the cancer, and that a slow response like mine is consistent with other indicators suggesting that my cancer moves slowly.
• I was initially diagnosed with "light chain-disease" five years ago, so I asked Dr L if I really do have light-chain disease. She preferred the term "light-chain deposition disease," and said that I do not have it. Apparently I have a rather garden-variety myeloma with an incidental, minor secretion of lambda light chains. In other words the myeloma cells themselves are the problem, not the the light chains, and that's actually a good thing.

Here are a few specific test results:

Test		May 29		Jun 26		Jul 24		Aug 22		Remarks
IgG mg/dL		1260		1450		1330		1040		Variation is normal
M-spike g/dL		1.2		1.1		1.1		1.0		Best tumor measure
L FLC mg/dL		4.25		4.03		3.30		3.57		Down is best
Calcium mg/dL		9.7		10.1		9.7		9.3		Below 1.2 is best
Creat mg/dL		1.1		1.0		1.0		1.3		Kidney, lower is better
HGB g/dL		14.5		14.8		14.3		13.8		Hemoglobin, a bit low
RBC M/uL		4.23		4.28		4.17		3.99		Red cell count, low

I'm no longer concerned about lambda free light chains (L FLC). Calcium is dandy. Creatinine is up, but it has been this high in the past. Hemoglobin and red blood cell count are down, but they have been lower. Albumin (liver function, not shown) is normal.

I feel so very lucky, still able to finish a half marathon when I know so many myelomiacs who could not. Live one day at a time and make it a masterpiece!