Myeloma Chemotherapy Drug Names
Printed August 12, 2012
Brand Name |
Generic Name |
Trial Name |
Manufacturer |
Comments |
Immunomodulatory Drugs (IMiDs) |
|
|
|
|
Thalomid |
Thalidomide |
|
Celgene |
All three have multiple mechanisms of anti-tumor action including modification of the immune system and anti-angiogenesis. |
Revlimid |
Lenalidomide |
|
Celgene |
|
Actimid (?) |
Pomalidomide |
CC-4047 |
Celgene |
|
|
|
|
|
|
Corticosteroids |
|
|
|
|
Decadron |
Dexamethasone |
|
Generic |
Not sure why these steroids help, but "Everything works better with DEX." |
|
Prednisone |
|
Generic |
|
|
|
|
|
|
Proteasome Inhibitors |
|
|
|
|
Velcade |
Bortezomib |
PS-341 |
Millennium |
These prevent rapidly-growing cells from discharging waste - both administered by infusion. |
Kyprolis |
Carfilzomib |
PR-171 |
Onyx |
|
|
Ixazomib |
MLN9708 |
Millennium |
First oral proteasome inhibitor |
|
|
|
|
|
Alkylating Agents |
|
|
|
|
Alkeran |
Melphalan |
|
GSK |
These drugs attach to the DNA of rapidly-dividing cells, damaging that DNA and thus the cells, but can also affect some normal cells. |
Cytoxan |
Cyclophosphamide |
|
Generic |
|
Busulfex, Myleran |
Busulfan |
|
|
|
BCNU |
Carmustine |
|
|
|
Treanda |
Bendamustine |
SDX-105 |
Cephalon |
|
|
|
|
|
|
Intercalating Agents |
|
|
|
|
Adriamycin, Rubex |
Doxorubicin |
|
Generic |
Actually a type of antibiotic |
Doxil |
Pegylated doxorubicin |
|
Generic |
Liopsome-encapsulated form, less toxic to the heart. |
Biaxin |
Clarithromycin |
|
|
Antibiotic. These attach to DNA also |
|
|
|
|
|
Mitotic Inhibitor |
|
|
|
|
Oncovin |
Vincristine |
|
Generic |
Derived from Madagascar periwinkle |
|
|
|
|
|
Histone deacetylase (HDAC) inhibitors |
|
|
|
|
Zolinza |
Vorinostat |
|
Patheon |
Activates genes which should control normal cell activity but are inhibited in myeloma |
|
|
|
|
|
Monoclonal Antibodies |
|
|
|
|
|
Siltuximab |
CNTO328 |
Janssen Biotech |
Targets IL6, a myeloma growth factor. Also ovarian cancer? |
|
|
BI-505 |
BioInvent |
Targets ICAM-1 |
|
Elotuzumab |
HuLuc63 |
Abbott/Squibb |
Targets CS1 |
HuMax-CD38 |
Daratumumab |
|
Genmab |
Targets CD38 |
|
|
|
|
|
mTOR Inhibitor |
|
|
|
|
Torisel |
Temsirolimus |
|
|
Inhibits mTOR, thereby blocking cell growth |
|
|
|
|
|
Bone Treatments |
|
|
|
|
Zometa |
Zoledronic acid |
|
Novartis |
Bisphosphonate |
Aredia |
Pamidronate disodium |
|
Novartis |
Bisphosphonate |
Prolia |
Denosumab |
|
Amgen |
Monoclonal antibody targeting RANKL |
|
|
|
|
|
Asparagine Inhibitor |
|
|
|
|
Oncaspar |
Pegaspargase |
|
Sigma-Tau |
Enzyme which destroys asparagine, needed by cancer cells |
|
|
|
|
|
CK2 Inhibitor |
|
|
|
|
|
|
CX-4945 |
Cylene |
Inhibits CK2 enzyme, required for myeloma cell proliferation |