Myeloma Chemotherapy Drug Names

Printed August 12, 2012


Brand Name

Generic Name

Trial Name

Manufacturer

Comments

Immunomodulatory Drugs (IMiDs)

 

 

 

 

Thalomid

Thalidomide

 

Celgene

All three have multiple mechanisms of anti-tumor action including modification of the immune system and anti-angiogenesis.

Revlimid

Lenalidomide

 

Celgene

Actimid (?)

Pomalidomide

CC-4047

Celgene

 

 

 

 

 

Corticosteroids

 

 

 

 

Decadron

Dexamethasone

 

Generic

Not sure why these steroids help, but "Everything works better with DEX."

 

Prednisone

 

Generic

 

 

 

 

 

Proteasome Inhibitors

 

 

 

 

Velcade

Bortezomib

PS-341

Millennium

These prevent rapidly-growing cells from discharging waste - both administered by infusion.

Kyprolis

Carfilzomib

PR-171

Onyx

 

Ixazomib

MLN9708

Millennium

First oral proteasome inhibitor

 

 

 

 

 

Alkylating Agents

 

 

 

 

Alkeran

Melphalan

 

GSK

These drugs attach to the DNA of rapidly-dividing cells, damaging that DNA and thus the cells, but can also affect some normal cells.

Cytoxan

Cyclophosphamide

 

Generic

Busulfex, Myleran

Busulfan

 

 

BCNU

Carmustine

 

 

Treanda

Bendamustine

SDX-105

Cephalon

 

 

 

 

 

Intercalating Agents

 

 

 

 

Adriamycin, Rubex

Doxorubicin

 

Generic

Actually a type of antibiotic

Doxil

Pegylated doxorubicin

 

Generic

Liopsome-encapsulated form, less toxic to the heart.

Biaxin

Clarithromycin

 

 

Antibiotic. These attach to DNA also

 

 

 

 

 

Mitotic Inhibitor

 

 

 

 

Oncovin

Vincristine

 

Generic

Derived from Madagascar periwinkle

 

 

 

 

 

Histone deacetylase (HDAC) inhibitors

 

 

 

 

Zolinza

Vorinostat

 

Patheon

Activates genes which should control normal cell activity but are inhibited in myeloma

 

 

 

 

 

Monoclonal Antibodies

 

 

 

 

 

Siltuximab

CNTO328

Janssen Biotech

Targets IL6, a myeloma growth factor. Also ovarian cancer?

 

 

BI-505

BioInvent

Targets ICAM-1

 

Elotuzumab

HuLuc63

Abbott/Squibb

Targets CS1

HuMax-CD38

Daratumumab

 

Genmab

Targets CD38

 

 

 

 

 

mTOR Inhibitor

 

 

 

 

Torisel

Temsirolimus

 

 

Inhibits mTOR, thereby blocking cell growth

 

 

 

 

 

Bone Treatments

 

 

 

 

Zometa

Zoledronic acid

 

Novartis

Bisphosphonate

Aredia

Pamidronate disodium

 

Novartis

Bisphosphonate

Prolia

Denosumab

 

Amgen

Monoclonal antibody targeting RANKL

 

 

 

 

 

Asparagine Inhibitor

 

 

 

 

Oncaspar

Pegaspargase

 

Sigma-Tau

Enzyme which destroys asparagine, needed by cancer cells

 

 

 

 

 

CK2 Inhibitor

 

 

 

 

 

 

CX-4945

Cylene

Inhibits CK2 enzyme, required for myeloma cell proliferation